Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH-I monoclonal antibody and E-rosetting
| Autor: | Lj Knott, R. J. Levinsky, G. Hale, David C. Linch, E. G. Davies, J. M. Chessells, Colin A. Sieff, Herman Waldmann, Gareth J. Morgan |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Rosette Formation Cyclophosphamide medicine.drug_class T-Lymphocytes T cell medicine.medical_treatment Cell Separation Monoclonal antibody medicine Humans Antigens Bone Marrow Transplantation Severe combined immunodeficiency Chemotherapy business.industry Immunologic Deficiency Syndromes Antibodies Monoclonal Infant Hematology medicine.disease Transplantation surgical procedures operative medicine.anatomical_structure Child Preschool Humoral immunity Immunology Female Bone marrow business medicine.drug |
| DOI: | 10.1111/j.1365-2141.1986.tb02953.x |
| Popis: | Six patients with severe combined immunodeficiency were transplanted with bone marrow from their HLA haploidentical parents. T-lymphocytes were removed by complement mediated lysis with a monoclonal antibody (CAMPATH-I) followed by rosetting with sheep erythrocytes. The patients were pre-conditioned with marrow ablative chemotherapy, using busulphan and cyclophosphamide. There was graft take in five patients, with evidence of transient acute graft-versus-host disease only. Three patients are alive and well greater than 5 months after transplant, and one who is 12 months post graft has full reconstitution of cell mediated and humoral immunity, including specific antibody response to immunization. Transplantation across major histocompatibility barriers can be successfully achieved using this method of treatment of donor marrow. |
| Databáze: | OpenAIRE |
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