In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
| Autor: | Chengpeng Bao, Zhongyu Liu, Kun Wang, Xiaojun Zhang, Haixiao Liu, Jing Wang, Jie Tian, Yawei Qu, Zhenhua Hu, Jiali Zha, Haifeng Liu, Zhongliang Wang, Tianming Song |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Photon Materials science Microscopy Acoustic Mice Nude General Physics and Astronomy chemistry.chemical_element Signal Article General Biochemistry Genetics and Molecular Biology Mice Europium Microscopy medicine Animals Medical physics Cherenkov radiation Multidisciplinary Optical Imaging General Chemistry Fluorescence chemistry Nanoparticles Female Radiopharmaceuticals Molecular imaging Luminescence Biomedical engineering |
| Zdroj: | Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms8560 |
| Popis: | Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts γ and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications. Insufficient imaging sensitivity can make it challenging to assess early stage tumour lesions in vivo. Here, the authors present the radiopharmaceutical-excited fluorescence imaging technique that can detect tumour lesions less than 2 mm in size in living mice. |
| Databáze: | OpenAIRE |
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