Association of RIT2 and RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and a meta-analysis in Asian populations
| Autor: | Tsai-Wei Liu, Chiung-Mei Chen, Hon Chung Fung, Yi-Chun Chen, Yih-Ru Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Aging Genotype Taiwan Locus (genetics) Disease Polymorphism Single Nucleotide Cohort Studies 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Humans Medicine Allele Alleles Aged Monomeric GTP-Binding Proteins Genetic association business.industry General Neuroscience Case-control study Parkinson Disease Middle Aged 030104 developmental biology rab GTP-Binding Proteins Case-Control Studies Meta-analysis Cohort Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Genome-Wide Association Study Developmental Biology Demography |
| Zdroj: | Neurobiology of Aging. 87:140.e5-140.e11 |
| ISSN: | 0197-4580 |
| Popis: | Several genome-wide association studies and meta-analyses on Parkinson's disease (PD)-related genes have identified several risk foci in Ras-related genes, particularly among Caucasian individuals. However, the corresponding results have been controversial among Asian individuals. We investigated whether 2 single-nucleotide polymorphisms of Ras-related genes, RIT2 (rs12456492) and RAB7L1 (rs823118), are associated with PD risk in Taiwanese individuals. In addition, we conducted a meta-analysis of all studies related to rs12456492 in Asian populations to resolve inconsistency in this locus. In total, 1103 Taiwanese individuals (588 patients with PD and 515 controls) and 1111 Taiwanese individuals (594 patients with PD and 517 controls) were genotyped for rs12456492 and rs823118. However, we could not confirm the association of rs12456492 and rs823118 with PD. Our current meta-analysis involving the rs12456492(A/G) variant demonstrated that the GG + GA genotypes, GG genotypes, and G allele may be risk factors for PD. RIT2 may increase PD risk in Asian individuals. The discrepancies between Caucasian and Asian populations may be due to differences in geographic region–specific genetic backgrounds and gene-environmental interactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect