Complementary interactions between command-like interneurons that function to activate and specify motor programs
| Autor: | Jia-Wei Gu, Ruo-nan Jia, Michael J. Siniscalchi, Matthew H. Perkins, Song-an Chen, Yi-Qing Qian, Wei Yu, Jian Jing, Ferdinand S. Vilim, Yutong Zheng, Nan Wang, Jin-Sheng Wu, Klaudiusz R. Weiss, Elizabeth C. Cropper, Yang Ye |
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| Rok vydání: | 2014 |
| Předmět: |
Patch-Clamp Techniques
Population Motor Activity Efferent Pathways Motor network Eating Feeding behavior Interneurons Aplysia Animals Motor activity education education.field_of_study biology General Neuroscience Neuropeptides Central pattern generator Feeding Behavior Articles biology.organism_classification Coactivation Immunohistochemistry Electrophysiological Phenomena Cheek Food Data Interpretation Statistical Neural coding Neuroscience |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(19) |
| ISSN: | 1529-2401 |
| Popis: | Motor activity is often initiated by a population of command-like interneurons. Command-like interneurons that reliably drive programs have received the most attention, so little is known about how less reliable command-like interneurons may contribute to program generation. We study two electrically coupled interneurons, cerebral-buccal interneuron-2 (CBI-2) and CBI-11, which activate feeding motor programs in the molluskAplysia californica. Earlier work indicated that, in rested preparations, CBI-2, a powerful activator of programs, can trigger ingestive and egestive programs. CBI-2 reliably generated ingestive patterns only when it was repeatedly stimulated. The ability of CBI-2 to trigger motor activity has been attributed to the two program-promoting peptides it contains, FCAP and CP2. Here, we show that CBI-11 differs from CBI-2 in that it contains FCAP but not CP2. Furthermore, it is weak in its ability to drive programs. On its own, CBI-11 is therefore less effective as a program activator. When it is successful, however, CBI-11 is an effective specifier of motor activity; that is, it drives mostly ingestive programs. Importantly, we found that CBI-2 and CBI-11 complement each other's actions. First, prestimulation of CBI-2 enhanced the ability of CBI-11 to drive programs. This effect appears to be partly mediated by CP2. Second, coactivation of CBI-11 with CBI-2 makes CBI-2 programs immediately ingestive. This effect may be mediated by specific actions that CBI-11 exerts on pattern-generating interneurons. Therefore, different classes of command-like neurons in a motor network may make distinct, but potentially complementary, contributions as either activators or specifiers of motor activity. |
| Databáze: | OpenAIRE |
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