Corallorazines from the myxobacterium Corallococcus coralloides
| Autor: | Martin Roth, Edith Neu, Till F. Schäberle, Alexander Schmitz, Stefan Kehraus, Celso Almeida, Gabriele M. König |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Molecular Structure Corallococcus coralloides Organic Chemistry Pharmaceutical Science Bacillus Chlorella Dipeptides Microbial Sensitivity Tests Biology Analytical Chemistry Microbiology Anti-Bacterial Agents Lactones Structure-Activity Relationship Complementary and alternative medicine Belgium Eurotium Drug Discovery Escherichia coli Molecular Medicine Myxococcales Nuclear Magnetic Resonance Biomolecular |
| Zdroj: | Journal of natural products. 77(1) |
| ISSN: | 1520-6025 |
| Popis: | The myxobacterium Corallococcus coralloides is the producer of the antibiotic compound corallopyronin A, which is currently in preclinical evaluation. To obtain suitable amounts of this antibiotic, the production strain C. coralloides B035 was cultured in large volumes, which in the addition to the isolation of the target molecule facilitates the detection of additional metabolites of this myxobacterial strain (corallorazines A-C). Corallorazine A is a new structural type of dipeptide composed of a dehydroalanine and a glycine moiety that are linked via a semiaminal bond, thus forming a piperazine ring. The latter is further connected via an amide bond to an unusual aliphatic acyl chain. |
| Databáze: | OpenAIRE |
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