Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860
| Autor: | María Jesús Citores, María Cañizares, Ana Duca, Valentín Cuervas-Mons, Isolina Baños, Clara Salas, Elisa Cisneros, Carlos Vilches, Isabel Millán, Ana Noblejas |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis Genotype medicine.medical_treatment Hepatitis C virus Hepacivirus Liver transplantation Real-Time Polymerase Chain Reaction medicine.disease_cause Gastroenterology Virus Recurrence Internal medicine medicine Humans Allele Alleles Aged Transplantation Polymorphism Genetic business.industry Interleukins Odds ratio Middle Aged medicine.disease Hepatitis C Liver Transplantation Multivariate Analysis Immunology Female Interferons business Liver Failure |
| Zdroj: | Transplantation. 94:275-280 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0b013e31825668f6 |
| Popis: | Background. Polymorphisms of the IL28B gene (encoding interferon-L3) determine the spontaneous course of hepatitis C virus (HCV) infection and its response to antiviral therapy. We investigated the influence of the IL28B rs12979860 (C9T) polymorphism on the risk of severe HCV recurrence after liver transplantation. Methods. Ninety patients who underwent transplantation because of HCV cirrhosis were retrospectively analyzed; forty-one (45.6%) of them with severe HCV recurrence. Forty-eight of their paired donors were available and were also analyzed. IL28B rs12979860 was genotyped by real-time polymerase chain reaction, and evaluated for association with severe HCV recurrence, along with other variables, by univariate and multivariate analyses. Results. The risk allele rs12979860-T was more common in transplanted patients (66.7%) than reported in healthy whites AQ1 , and it was significantly overrepresented among patients with severe HCV recurrence, in comparison with patients without it (82.9% vs. 53.1%, odds ratio [OR]=4.30, etiologic fraction=63.6%; P=0.0028). Furthermore, separate analysis of the recipients’ genotypes indicated that the risk of severe HCV recurrence increased with the dose of the T allele (linear trend, P=0.0068). Multiple logistic regression analysis confirmed the contribution of the IL28B genotype to the risk of severe HCV recurrence (OR=4.27; P=0.014), independently of other associated factors. Allele IL28B T in the donor seemed to have an opposite effect than that in the recipient (OR=0.46), but the study was underpowered to demonstrate this unforeseen effect (P=0.1995). Conclusions. The recipient IL28B rs12979860 genotype has a major influence on the posttransplantation course of HCV infection, being a valuable biomarker for patient care in liver transplantation. |
| Databáze: | OpenAIRE |
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