An Indonesian Marine Bacterium, Pseudoalteromonas rubra, Produces Antimicrobial Prodiginine Pigments
| Autor: | Renny Indrawati, Marcelinus A. S. Adhiwibawa, Yuzo Shioi, Edi Setiyono, Tatas H. P. Brotosudarmo, Monika Nur Utami Prihastyanti |
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| Rok vydání: | 2020 |
| Předmět: |
biology
General Chemical Engineering General Chemistry medicine.disease_cause 16S ribosomal RNA Antimicrobial biology.organism_classification Microbiology Prodigiosin Chemistry chemistry.chemical_compound Marine bacteriophage chemistry Staphylococcus aureus medicine Candida albicans QD1-999 Escherichia coli Bacteria |
| Zdroj: | ACS Omega, Vol 5, Iss 9, Pp 4626-4635 (2020) |
| ISSN: | 2470-1343 |
| DOI: | 10.1021/acsomega.9b04322 |
| Popis: | Red pigmented marine bacteria, Pseudoalteromonas rubra strains PS1 and SB14, were isolated from two sampling locations in different ecosystems on Alor Island, Indonesia, and cultured in the laboratory. We analyzed the 16S rRNA gene sequences and examined the pigment composition and found that both strains produced cycloprodigiosin (3), prodigiosin (4), and 2-methyl-3-hexyl-prodiginine (5) as major compounds. In addition, we detected three minor compounds: prodigiosin derivatives 2-methyl-3-propyl prodiginine (1), 2-methyl-3-butyl prodiginine (2), and 2-methyl-3-heptyl-prodiginine (6). To our knowledge, this is the first report that P. rubra synthesizes not only prodigiosin and cycloprodigiosin but also four prodigiosin derivatives that differ in the length of the alkyl chain. The antimicrobial activity of cycloprodigiosin, prodigiosin, and 2-methyl-3-hexyl-prodiginine was examined by a disk-diffusion test against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Candida albicans. We found that, at a concentration of 20 μg/mL, cycloprodigiosin showed the greatest inhibition (25.1 ± 0.55 mm) against S. aureus. |
| Databáze: | OpenAIRE |
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