| Autor: |
Zening Men, Xiaotong Lu, Ting He, Mengfang Wu, Tong Su, Teng Shen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International journal of pharmaceutics. 612 |
| ISSN: |
1873-3476 |
| Popis: |
The painless microneedle patch (MNP), widely explored for transdermal drug delivery of macromolecules, can overcome the limitations of traditional administrations of protein and polypeptide anticoagulant drugs. We constructed a recombinant hirudin-loaded microneedle patch, suitable for patients with thrombotic diseases requiring long-term preventive medication. The recombinant hirudin-loaded dissoluble microneedle patch (RHDMNP) was created using a mold casting technique and polyvinylpyrrolidone and polyvinyl alcohol were used as the matrix material with a 1:1.2 ratio. We prepared bilayer RHDMNPs with pyramidal appearance and 0.37 N/needle strength. The intradermal dissolution height of the microneedle reached approximately 78.67% of the total height, and 68.12% of the drug was delivered into the skin. The 12-hour cumulative permeation of the MNP was 21.69 ± 3.90 μg/cm |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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