IGF1 modifications after bariatric surgery in morbidly obese patients: potential implications of nutritional status according to specific surgical technique
| Autor: | Elena Guanyabens, Pau Moreno, M. Navarro, Assumpta Serra, María Luisa Granada, Eva Martínez, Silvia Pellitero, José María Balibrea, Manel Puig-Domingo, Ramón Romero, Antonio Alastrué |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Sleeve gastrectomy Endocrinology Diabetes and Metabolism medicine.medical_treatment Bariatric Surgery Nutritional Status Body Mass Index Endocrinology Insulin resistance Weight loss Internal medicine Odds Ratio medicine Homeostasis Humans Insulin Prospective Studies Insulin-Like Growth Factor I Prospective cohort study Serum Albumin business.industry General Medicine Odds ratio Middle Aged medicine.disease Lipids Obesity Ghrelin Obesity Morbid Surgery Insulin-Like Growth Factor Binding Protein 3 Hypertension Regression Analysis Female Insulin Resistance medicine.symptom business Body mass index |
| Zdroj: | European Journal of Endocrinology. 169:695-703 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-13-0209 |
| Popis: | ObjectivesIGF1 is decreased in morbidly obese (MO) patients and its changes after bariatric surgery weight loss (WL) are not well known. The aim of this study was to analyse IGF1 modifications in MO patients after WL and its relationship to ghrelin and to different types of surgeries.DesignRetrospective follow-up study at the University Medical Center.MethodsOne hundred and nine MO patients (age 44.1±9.3, BMI 51.74±8.75 kg/m2) were evaluated at baseline and 1 year after surgery: 28 sleeve gastrectomy (SG), 31 distal modified (m), and 50 ringed (r) Roux-en-Y gastric bypass (RYGBP) surgery. Changes in IGF1, IGFBP3, ratio IGF1:IGFBP3, and ghrelin were evaluated 1 year after surgery.ResultsBaseline prevalence of low IGF1 (defined bys.d.IGF1PP=0.03) and did not change in RYGPBP techniques. The %albumin change was the only dependent variable associated with the % total IGF1 change.ConclusionsRecovery of low IGF1 after bariatric surgery was specifically related to the albumin modifications induced by surgery and was not related to ghrelin modifications. |
| Databáze: | OpenAIRE |
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