β-Estradiol Inhibits Na+-PiCotransport across Renal Brush Border Membranes from Ovarectomized Rats
| Autor: | Michael A. Thompson, Thomas P. Dousa, Eduardo N. Chini, Kelly W. Beers |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Brush border medicine.drug_class Ovariectomy Biophysics Kidney Biochemistry Rats Sprague-Dawley Internal medicine medicine Pi Animals Receptor Molecular Biology Estradiol Microvilli Symporters urogenital system Chemistry Reabsorption Sodium-Phosphate Cotransporter Proteins Cell Biology Pathophysiology Rats medicine.anatomical_structure Endocrinology Estrogen Female Carrier Proteins Cotransporter hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and Biophysical Research Communications. 221:442-445 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1996.0614 |
| Popis: | Estrogens play a major role in mineral homeostasis, however it remains unclear whether they exert regulatory action upon reabsorption of phosphate (P i ) in proximal tubules of the kidney. We investigated the effect of β-estradiol (E 2 ) injected to thyroparathyrodectomized and ovarectomized rats upon Na + -cotransport of P i and other solutes across renal brush border membrane (BBM). In BBM from kidneys of E 2 -treated rats the capacity for Na + -P i cotransport was considerably suppressed (Δ% − 42; P + -cotransports of L-proline D-glucose and SO 4 across the same BBM did not differ from controls. We surmise that E 2 inhibits selectively Na + -P i cotransport by direct interaction with E 2 receptors in proximal tubular cells. These results indicate the existence of the inhibitory effect of estrogens upon renal proximal tubular Na + -P i cotransport and, by extention, proximal Pi reabsorption. We suggest that this modulatory action of E 2 plays a role in pathophysiology of mineral metabolism due to estrogen deficiency and should be considered when estrogens are used for pharmacotherapy of postmenopausal osteoporosis and some types of cancer. |
| Databáze: | OpenAIRE |
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