Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression
| Autor: | Alexandra Hall, Mary Kathryn Bohn, Benjamin Jung, Shannon Steele, Lusia Sepiashvili, Khosrow Adeli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Physiology Pneumonia Viral Review Bioinformatics Asymptomatic Betacoronavirus 03 medical and health sciences 0302 clinical medicine Immune system Viral entry Epidemiology Humans Medicine 030212 general & internal medicine coagulation multisystem organ failure Pandemics pathophysiolog SARS-CoV-2 business.industry COVID-19 medicine.disease Pathophysiology 3. Good health 030104 developmental biology Underlying disease cytokine storm Disease Progression Cytokines medicine.symptom Coronavirus Infections business Cytokine storm |
| Zdroj: | Physiology |
| ISSN: | 1548-9221 1548-9213 |
| DOI: | 10.1152/physiol.00019.2020 |
| Popis: | The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death. |
| Databáze: | OpenAIRE |
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