Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia
| Autor: | Kevin R. Krull, Kirsten K. Ness, Ching-Hon Pui, Daniel M. Green, Melissa M. Hudson, E. Brannon Morris, Tseng T. Huang, Leslie L. Robison |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research Vincristine Pediatrics medicine.medical_specialty medicine.medical_treatment Article Young Adult Antineoplastic Combined Chemotherapy Protocols Humans Medicine Survivors Young adult Survival rate Childhood Acute Lymphoblastic Leukemia Neoplasm Staging Chemotherapy business.industry Late effect Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Neuromuscular Junction Diseases Prognosis medicine.disease Survival Rate Methotrexate Oncology Neuromuscular junction disease Physical therapy Female medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Cancer. 118:828-838 |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND: Treatment regimens for childhood acute lymphoblastic leukemia (ALL) contain neurotoxic agents that may interfere with neuromuscular health. In this study, the authors examined associations between neuromuscular impairments and physical function and between neuromuscular impairments and doses of vincristine and intrathecal methotrexate used to treat leukemia among survivors of childhood ALL. METHODS: ALL survivors >10 years from diagnosis participated in neuromuscular performance testing. Treatment data were abstracted from medical records. Regression models were used to evaluate associations between treatment factors, neuromuscular impairments, and physical performance. RESULTS: Among 415 survivors (median age, 35 years; age range, 21-52 years), balance, mobility, and 6-minute walk (6MW) distances were 1.3 standard deviations below age-specific and sex-specific values in 15.4%, 3.6%, and 46.5% of participants, respectively. Impairments included absent Achilles tendon reflexes (39.5%), active dorsiflexion range of motion (ROM) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text