Pathomechanism and Biomechanics of Degenerative Disc Disease: Features of Healthy and Degenerated Discs
| Autor: | Roger Härtl, Marianne Lintz, Charisse Capadona, Rachel Yerden, Branden Medary, Byumsu Kim, Lynn B. McGrath, Jacob L. Goldberg, Sertac Kirnaz, Fabian Sommer, Lawrence J. Bonassar |
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| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
musculoskeletal diseases Pathology medicine.medical_specialty Future studies business.industry Biomechanics Intervertebral disc Degeneration (medical) medicine.disease musculoskeletal system Degenerative disc disease 03 medical and health sciences 0302 clinical medicine Vascularity medicine.anatomical_structure Axial compression medicine Orthopedics and Sports Medicine Surgery Disc Biology medicine.symptom business Process (anatomy) 030217 neurology & neurosurgery |
| Zdroj: | Int J Spine Surg |
| ISSN: | 2211-4599 |
| Popis: | The human intervertebral disc (IVD) is a complex organ composed of fibrous and cartilaginous connective tissues, and it serves as a boundary between 2 adjacent vertebrae. It provides a limited range of motion in the torso as well as stability during axial compression, rotation, and bending. Adult IVDs have poor innate healing potential due to low vascularity and cellularity. Degenerative disc disease (DDD) generally arises from the disruption of the homeostasis maintained by the structures of the IVD, and genetic and environmental factors can accelerate the progression of the disease. Impaired cell metabolism due to pH alteration and poor nutrition may lead to autophagy and disruption of the homeostasis within the IVD and thus plays a key role in DDD etiology. To develop regenerative therapies for degenerated discs, future studies must aim to restore both anatomical and biomechanical properties of the IVDs. The objective of this review is to give a detailed overview about anatomical, radiological, and biomechanical features of the IVDs as well as discuss the structural and functional changes that occur during the degeneration process. |
| Databáze: | OpenAIRE |
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