In vivo studies of ethanol on prolactin and luteinizing hormone in rats and mice
| Autor: | Nicholas V. Emanuele, A. M. Lawrence, L. Kirsteins, C. Ho |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Alcohol Drinking medicine.drug_class medicine.medical_treatment Intraperitoneal injection Hypothalamus Drinking Behavior Body weight Mice chemistry.chemical_compound In vivo Internal medicine medicine Animals Ethanol Chemistry Rats Inbred Strains General Medicine Luteinizing Hormone Prolactin Rats Mice Inbred C57BL Endocrinology Gonadotropin Luteinizing hormone |
| Zdroj: | International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 19:737-740 |
| ISSN: | 0883-2897 |
| DOI: | 10.1016/0883-2897(92)90133-j |
| Popis: | The interaction of ethanol (EtOH), prolactin (Prl) and luteinizing hormone (LH) was examined in two studies. In the first study, adult male C57 B1/6J mice were given a single intraperitoneal injection of either vehicle or Prl at 5, 10 and 20 mg/kg and a significant dose-related suppression of ethanol consumption was found. This injection did not cause any differences in food intake or body weight. Additionally, a 5 mg/kg dose of Prl was also given to adult male Long Evans Hooded rats and, similarly, there was a significant suppression of ethanol consumption. In a second study, when rats were given a free choice between water and 5% EtOH, three subgroups were found regarding the amount of EtOH consumption: low, medium and high. After 2 weeks of free choice, hypothalamic, but not serum Prl and LH levels, were significantly increased in EtOH-imbibing groups compared to controls. These findings suggest important interactions between EtOH consumption and ambient levels of Prl and LH. |
| Databáze: | OpenAIRE |
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