Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease Possible role for left ventricular remodelling
| Autor: | Toshiro Matsunaga, Tomohiro Osanai, Ken Okumura, Hirotsugu Ono, Hiroshi Ishizaka, Naoki Abe, Masayuki Saitoh, Kozo Fukui, Hiroyuki Hanada, Kunihiko Kameda, Ikuo Fukuda |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Coronary Artery Disease Matrix metalloproteinase medicine.disease_cause Coronary artery disease Coronary artery bypass surgery Internal medicine medicine Humans Zymography Aged Prostaglandins A Ventricular Remodeling business.industry Pericardial fluid medicine.disease Matrix Metalloproteinases Oxidative Stress Heart failure Circulatory system Cardiology Female Cardiology and Cardiovascular Medicine business Pericardium Oxidative stress |
| Zdroj: | European Heart Journal. 24:2180-2185 |
| ISSN: | 0195-668X |
| Popis: | Aim Oxidative stress is implicated in the progression of heart failure, and matrix metalloproteinase (MMP) activity is increased in patients with congestive heart failure. We examined the role of oxidative stress on MMP activity in humans. Methods and results We measured the MMP activity and the level of 8-iso-prostagandin F2α (8-iso-PGF2α), a specific and quantitative maker of oxidant stress, in the pericardial fluid (PF) in 47 consecutive patients with coronary artery disease who underwent coronary artery bypass surgery. Zymography of PF showed bands at 92–85kDa (MMP-9) and 72–65kDa (MMP-2). The MMP activity was expressed as the ratio to MMP-2 standard. MMP-2, MMP-9 and total gelatinolysis activities were positively correlated with left ventricular end-diastolic volume index (LVEDVI), and MMP-2 and total gelatinolysis activities were also positively correlated with LV end-systolic volume index. Moreover, MMP-2, MMP-9 and total gelatinolysis activities were all positively correlated with pericardial level of 8-iso-PGF2α. Also, LVDEVI was positively correlated with pericardial level of 8-iso-PGF2α. Conclusion Oxidative stress may play an important role in the regulation of MMP activity. Augmented MMP activity may be involved in the development of ventricular remodelling in patients with coronary artery disease. |
| Databáze: | OpenAIRE |
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