Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians
| Autor: | Norzian Ismail, Patimah Ismail, Polin Haghvirdizadeh, Ali Etemad, Vasudevan Ramachandran, Farzad Heidari, Nooshin Ghodsian |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Genotype Article Subject endocrine system diseases Endocrinology Diabetes and Metabolism Biology Polymerase Chain Reaction lcsh:Diseases of the endocrine glands. Clinical endocrinology Body Mass Index Endocrinology Insulin resistance Asian People Gene Frequency Risk Factors Genetic variation ABCA1 Gene medicine Humans Allele Allele frequency Alleles Aged Genetics Polymorphism Genetic lcsh:RC648-665 Malaysia Genetic Variation Type 2 Diabetes Mellitus nutritional and metabolic diseases Middle Aged medicine.disease ATP Binding Cassette Transporter 1 Diabetes Mellitus Type 2 Female Research Article |
| Zdroj: | Journal of Diabetes Research, Vol 2015 (2015) Journal of Diabetes Research |
| ISSN: | 2314-6753 2314-6745 |
| Popis: | Background. Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors. ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms are reported as the one of the genetic risk factors for T2DM in various populations with conflicting results. This study was conducted based on PCR-HRM to determine the frequency of ABCA1 gene by rs2230806 (R219K), rs1800977 (C69T), and rs9282541 (R230C) polymorphisms Malaysian subjects.Methods. A total of 164 T2DM and 165 controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the real time high resolution melting analysis.Results. There was a significant difference between the subjects in terms of age, BMI, FPG, HbA1c, HDL, LDL, and TGP<0.05. There was a significant association between HOM of R219KP=0.005, among Malaysian subjects; moreover, allele frequency revealed the significant difference in A allele of R219KP=0.003. But, there was no significant difference in genotypic and allelic frequencies of C69T and R230C polymorphism.Conclusion. R219K polymorphism of ABCA1 gene can be considered as a genetic risk factor for T2DM subjects among Malaysians. |
| Databáze: | OpenAIRE |
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