The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults
| Autor: | Jérôme Gariepy, Dragan Milenkovic, Augustin Scalbert, Catherine M.G.C. Renard, Gilles Chironi, Sylvain Auclair, J-L Mégnien, Peter C. H. Hollman, J-L Paul, A. Simon |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, FLAVO-FOOD-CT-2004-513960, Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
coronary-artery-disease Homocysteine Brachial Artery 030309 nutrition & dietetics Medicine (miscellaneous) Physiology cardiovascular-disease postmenopausal women antioxidant capacity 030204 cardiovascular system & hematology law.invention Body Mass Index chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Risk Factors [SDV.IDA]Life Sciences [q-bio]/Food engineering oxidative stress Endothelial dysfunction Brachial artery 0303 health sciences Nutrition and Dietetics Cross-Over Studies food and beverages healthy-young adults Middle Aged Lipids 3. Good health phenolic-acids Vasodilation medicine.anatomical_structure Malus Rikilt B&T Toxicologie en Effectanalyse medicine.medical_specialty Endothelium Hypercholesterolemia vascular function FMD 03 medical and health sciences Double-Blind Method Phenols Internal medicine medicine.artery medicine Humans [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering dependent dilation VLAG Flavonoids Vascular disease business.industry Cholesterol Apple Polyphenols medicine.disease Atherosclerosis Crossover study Endocrinology Freeze Drying chemistry flavonoid intake Fruit Dietary Supplements Patient Compliance Endothelium Vascular business |
| Zdroj: | European Journal of Clinical Nutrition European Journal of Clinical Nutrition, Nature Publishing Group, 2010, 64 (10), pp.1158-1165. ⟨10.1038/ejcn.2010.135⟩ European Journal of Clinical Nutrition, Nature Publishing Group, 2010, ⟨10.1038/ejcn.2010.135⟩ European Journal of Clinical Nutrition, 64, 1158-1165 European Journal of Clinical Nutrition 64 (2010) |
| ISSN: | 0954-3007 1476-5640 |
| DOI: | 10.1038/ejcn.2010.135⟩ |
| Popis: | International audience; Background/objectives: Epidemiological studies suggest that apple consumption is associated to a reduction of cardiovascular disease risk. Apple polyphenols may contribute to explain these effects. Endothelial dysfunction has been associated with early stage of atherosclerosis and polyphenols from various dietary sources have been shown to reverse it. The aim of the present study was to investigate the effect of the consumption of a polyphenol-rich apple on endothelial function. Subjects/methods: Thirty hypercholesterolemic volunteers were included in a doubled-blinded randomized cross-over trial. They successively consumed 40 g of two lyophilised apples, polyphenol-rich and polyphenol-poor, providing respectively 1.43 and 0.21 g polyphenols per day during two 4-week periods separated by a 4-week washout period. Results: Brachial artery flow-mediated dilation (FMD) was assessed at the beginning and at the end of each intervention period. FMD did not differ between the polyphenol-rich and the polyphenol-poor apples, neither other cardiovascular disease risk factors (plasma lipids, homocysteine, antioxidant capacity). Conclusions: These data suggest that over a 4-week period, the consumption of a polyphenol-rich apple does not improve vascular function in hypercholesterolemic patients. |
| Databáze: | OpenAIRE |
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