Sexually Dimorphic Influence of Neonatal Antibiotics on Bone
| Autor: | Damian C. Genetos, Alice Wong, Matteo M. Pusceddu, Patricia Stokes, Mélanie G. Gareau |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Anabolism Antibiotics Physiology 02 engineering and technology Disease Gut flora Inbred C57BL bone antibiotics Mice 0302 clinical medicine Medicine Orthopedics and Sports Medicine Pediatric Sex Characteristics Gut barrier biology computer.file_format Skeleton (computer programming) Anti-Bacterial Agents Phenotype Female Infection medicine.drug_class Colon 0206 medical engineering Clinical Sciences Biomedical Engineering Article Bone and Bones Permeability 03 medical and health sciences Vancomycin Animals 030203 arthritis & rheumatology gut microbiota business.industry Neomycin Human Movement and Sports Sciences biology.organism_classification Newborn 020601 biomedical engineering Gastrointestinal Microbiome Mice Inbred C57BL Sexual dimorphism intestinal barrier Good Health and Well Being Orthopedics Animals Newborn Musculoskeletal Ampicillin ABX test business computer |
| Zdroj: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society, vol 37, iss 10 J Orthop Res |
| Popis: | The gut microbiome (GM) contributes to host development, metabolism, and disease. Perturbations in GM composition, elicited through chronic administration of oral antibiotics (Abx) or studied using germ-free environments, alter bone mass, and microarchitecture. However, studies primarily involved chronic Abx exposure to adult mice prior to evaluating the skeletal phenotype. Children are more prone to infection with bacterial pathogens than adults and are thus treated more frequently with broad-spectrum Abx; consequently, Abx treatment disproportionately occurs during periods of greatest skeletal plasticity to anabolic cues. Because early-life exposures may exert long-lasting effects on adult health, we hypothesized that acute Abx administration during a developmentally sensitive period would elicit lasting effects on the skeletal phenotype. To test this hypothesis, neonatal mice were treated with Abx (P7-P23; oral gavage) or vehicle (water); GM composition, gut physiology, and bone structural and material properties were assessed in adulthood (8 weeks). We found sexually dimorphic effects of neonatal Abx administration on GM composition, gut barrier permeability, and the skeleton, indicating a negative role for neonatal Abx on bone mass and quality. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2122-2129, 2019. |
| Databáze: | OpenAIRE |
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