The feasibility of prostate-specific membrane antigen positron emission tomography(PSMA PET/CT)-guided radiotherapy in oligometastatic prostate cancer patients

Autor: Hendrik Everaert, Cem Onal, R. Van den Begin, Ozan Cem Guler, M. De Ridder, Thierry Gevaert, Benedikt Engels
Přispěvatelé: Faculty of Medicine and Pharmacy, Clinical sciences, Medical Imaging, Supporting clinical sciences, Translational Radiation Oncology and Physics, Radiation Therapy
Rok vydání: 2017
Předmět:
Oncology
Male
medicine.medical_specialty
Cancer Research
medicine.medical_treatment
Urology
Gallium Radioisotopes
Prostate-specific membrane antigen
Kaplan-Meier Estimate
030218 nuclear medicine & medical imaging
Androgen deprivation therapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Paraaortic lymph nodes
Internal medicine
Positron Emission Tomography Computed Tomography
medicine
Humans
Neoplasm Metastasis
Edetic Acid
Gallium Isotopes
Aged
Retrospective Studies
Univariate analysis
medicine.diagnostic_test
business.industry
image-guided radiotherapy
Prostatic Neoplasms
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Oligometastatic prostate cancer
Radiation therapy
Positron emission tomography
030220 oncology & carcinogenesis
Toxicity
oncology
Feasibility Studies
Radiotherapy
Intensity-Modulated
Radiopharmaceuticals
business
Oligopeptides
RADIOTHERAPY
Radiotherapy
Image-Guided
Zdroj: Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 20(4)
ISSN: 1699-3055
Popis: Background: To investigate the efficacy and toxicity of 68Ga-PSMA-HBED-CC ( 68Ga-PSMA) PET-CT-guided RT in the treatment of oligometastatic prostate cancer retrospectively. Methods: A total of 23 prostate cancer patients with biochemical relapse, of which 13 were castration sensitive (CS) and 10 castration resistant (CR), were treated with intensity-modulated and image-guided RT (IMRT-IGRT) on ≤3 metastases detected by 68Ga PSMA PET-CT. Androgen deprivation therapy was continued in CR patients. Results: A total of 38 metastases were treated. The involved sites were pelvic bone (n = 16), pelvic lymph nodes (n = 11), paraaortic lymph nodes (n = 6), ribs (n = 3) and vertebral body (n = 2). The median PSA prior to RT was 1.1 ng/mL (range 0.1–29.0 ng/mL). A median dose of 43.5 Gy (range 30–64 Gy) was delivered by IMRT-IGRT in 12–27 fractions. At a median follow-up of 7 months (range 2–17 months), 19 patients (83%) were in remission. Four patients (17%) developed distant recurrences. The actuarial 1-year LC, PFS and OS rates were 100, 51 (95% CI 8–83%) and 100%. Univariate analysis demonstrated a statistically significantly better PFS in CS patients as compared to CR patients (1-year PFS 67 vs. 0%, p
Databáze: OpenAIRE
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