Reversal of residual neuromuscular block with neostigmine or sugammadex and postoperative pulmonary complications: a prospective, randomised, double-blind trial in high-risk older patients
| Autor: | Lucy Chan, Pui San Loh, Hong Seuk Yang, Béla Fülesdi, Zoltán Szabó-Maák, Berwin Turlach, Thomas Ledowski, Ina Ismiarti Shariffuddin, Hans Donald de Boer, László Asztalos |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Risk Sugammadex 03 medical and health sciences Postoperative Complications 0302 clinical medicine Double-Blind Method 030202 anesthesiology medicine Humans Prospective Studies Rocuronium Adverse effect Geriatric Assessment Aged Aged 80 and over business.industry Incidence Incidence (epidemiology) Australia Retrospective cohort study Neostigmine Clinical trial Treatment Outcome Anesthesiology and Pain Medicine Anesthesia Cohort Neuromuscular Blockade Female Cholinesterase Inhibitors Respiratory Insufficiency business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 127:316-323 |
| ISSN: | 0007-0912 |
| DOI: | 10.1016/j.bja.2021.04.026 |
| Popis: | Background Residual neuromuscular block is associated with an increased risk of postoperative pulmonary complications in retrospective studies. The aim of our study was to investigate prospectively the incidence of postoperative pulmonary complications after reversal with either sugammadex (SUG) or neostigmine (NEO) in high-risk older patients. Methods We randomly allocated 180 older patients with significant morbidity (ASA physical status 3) ≥75 yr old to reversal of rocuronium with either SUG or NEO. Adverse events in the recovery room and pulmonary complications (defined by a 5-point [0–4; 0=best to 4=worst] outcome score) on postoperative Days 1, 3, and 7 were compared between groups. Results Data from 168 patients aged 80 (4) yr were analysed; SUG vs NEO resulted in a reduced probability (0.052 vs 0.122) of increased pulmonary outcome score (impaired outcome) on postoperative Day 7, but not on Days 1 and 3. More patients in the NEO group were diagnosed with radiographically confirmed pneumonia (9.6% vs 2.4%; P=0.046). The NEO group showed a non-significant trend towards longer hospital length of stay across all individual centres (combined 9 vs 7.5 days), with a significant difference in Malaysia (6 vs 4 days; P=0.011). Conclusions Reversal of rocuronium neuromuscular block with SUG resulted in a small, but possibly clinically relevant improvement in pulmonary outcome in a select cohort of high-risk older patients. Clinical trial registration ACTRN12614000108617. |
| Databáze: | OpenAIRE |
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