A retrospective study of columnar alteration with prominent apical snouts and secretions and the association with cancer
| Autor: | Richard L. White, Wayne N. Christensen, Melissa M. Guerra-Wallace |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Incidence (epidemiology) Mammary gland Biopsy Needle Cancer Retrospective cohort study Breast Neoplasms General Medicine medicine.disease Breast cancer medicine.anatomical_structure Surgical biopsy Biopsy medicine Atypia Humans Surgery Female business Retrospective Studies |
| Zdroj: | American journal of surgery. 188(4) |
| ISSN: | 0002-9610 |
| Popis: | Background Columnar alteration with prominent snouts and secretions (CAPSS) is routinely described on breast core needle biopsies (CNBs); however, its significance and appropriate treatment is unknown. This study evaluated the incidence of cancer (in situ/invasive) in core biopsies and in subsequent surgical biopsy specimens after an initial core biopsy identifying CAPSS. Methods Using our medical center's pathology database, we retrospectively identified lesions described as CAPSS on breast core needle biopsies performed between January 1998 and August 2003. The specimens were subdivided into CAPSS lesions with and without atypical features. We also identified lesions described as atypical ductal hyperplasia. Results Overall, 10 cancers were associated with 135 (7.4%) CAPSS lesions without atypia, and 11 (18.3%) were associated with 60 CAPSS lesions with atypia ( P = 0.023). CAPSS lesions with atypical features had a slightly higher rate of coexisting cancer on initial biopsy than CAPSS without atypical features (7% vs 12%, P = 0.320). Specimens showing atypical ductal hyperplasia on initial biopsy had a greater rate of coexisting cancer than CAPSS with or without atypical features ( P Conclusion We support the existing recommendation that a patient with a CNB showing CAPSS with atypical features undergo surgical biopsy. |
| Databáze: | OpenAIRE |
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