Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model
| Autor: | Zonggao Shi, M. Sharon Stack, Marielle Blumenthaler, Tyvette S. Hilliard, Yuliya Klymenko, Jing Yang, Marwa Asem, Yueying Liu, Jeffrey J. Johnson, Annemarie K. Leonard, Elizabeth Loughran, Laura Tarwater, Matthew Leevy, Ryan C. Phan, Matthew J. Ravosa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Adipose tissue Disease Carcinoma Ovarian Epithelial Article Metastasis 03 medical and health sciences Peritoneal Neoplasm Mice Peritoneum Interferon Pregnancy Risk Factors medicine Animals Neoplasms Glandular and Epithelial Neoplasm Metastasis Peritoneal Neoplasms Ovarian Neoplasms business.industry Cancer medicine.disease Allografts Mice Inbred C57BL Disease Models Animal Parity 030104 developmental biology medicine.anatomical_structure Oncology Adipose Tissue Immunology Cancer research Female Disease Susceptibility Interferons Ovarian cancer business Neoplasm Transplantation medicine.drug |
| Zdroj: | Cancer letters. 411 |
| ISSN: | 1872-7980 |
| Popis: | Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer metastasis. Here we report that multiparous mice are less susceptible to ovarian cancer metastasis in an age-matched syngeneic murine allograft model. Interferon pathways were found to be upregulated in healthy adi-pose tissue of multiparous mice, suggesting a possible mechanism for the multiparous-related protective effect against metastasis. This protective effect was found to be lost with age. Based on this work, future studies exploring therapeutic strategies which harness the multiparity-associated protective effect demonstrated here are warranted. |
| Databáze: | OpenAIRE |
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