An Approach for Assessing Turbulent Flow Damage to Blood in Medical Devices
| Autor: | Mesude Ozturk, Dimitrios V. Papavassiliou, Edgar A. O'Rear |
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| Rok vydání: | 2016 |
| Předmět: |
Length scale
Materials science Capillary action 0206 medical engineering Biomedical Engineering Blood Pressure 02 engineering and technology 030204 cardiovascular system & hematology Hemolysis Models Biological Physics::Fluid Dynamics 03 medical and health sciences symbols.namesake 0302 clinical medicine Elastic Modulus Tensile Strength Physiology (medical) medicine Humans Computer Simulation Couette flow Simulation Turbulence Erythrocyte Membrane Kolmogorov microscales Mechanics Blood Viscosity medicine.disease 020601 biomedical engineering Flow conditions Equipment and Supplies Eddy symbols Stress Mechanical Shear Strength Blood Flow Velocity |
| Zdroj: | Journal of Biomechanical Engineering. 139 |
| ISSN: | 1528-8951 0148-0731 |
| Popis: | In this work, contributing factors for red blood cell (RBC) damage in turbulence are investigated by simulating jet flow experiments. Results show that dissipative eddies comparable or smaller in size to the red blood cells cause hemolysis and that hemolysis corresponds to the number and, more importantly, the surface area of eddies that are associated with Kolmogorov length scale (KLS) smaller than about 10 μm. The size distribution of Kolmogorov scale eddies is used to define a turbulent flow extensive property with eddies serving as a means to assess the turbulence effectiveness in damaging cells, and a new hemolysis model is proposed. This empirical model is in agreement with hemolysis results for well-defined systems that exhibit different exposure times and flow conditions, in Couette flow viscometer, capillary tube, and jet flow experiments. |
| Databáze: | OpenAIRE |
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