Cardiac function during iron chelation therapy in adult non-thalassaemic patients with transfusional iron overload
| Autor: | J. P. Bagger, F. T. Jensen, Jørgen Ellegaard, Paw Jensen, N. Olsen, T. Christensen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cardiac function curve
Adult Male medicine.medical_specialty Liver Iron Concentration Aging Iron Overload Heart disease Adolescent Injections Subcutaneous Antidotes Ascorbic Acid Deferoxamine Coronary Angiography Ventricular Function Left Radionuclide angiography Internal medicine medicine Humans Aged Chelating Agents Ejection fraction medicine.diagnostic_test Vitamin C business.industry beta-Thalassemia Transfusion Reaction Hematology General Medicine Middle Aged medicine.disease Endocrinology Heart failure cardiovascular system Cardiology Female business medicine.drug |
| Zdroj: | European journal of haematology. 59(4) |
| ISSN: | 0902-4441 |
| Popis: | It is well-documented that iron chelation by desferrioxamine protects/improves the cardiac function in blood transfusion-dependent children suffering from s-thalassaemia. In patients who do not become dependent upon blood transfusion until adulthood (ANT-patients), iron chelation by desferrioxamine may affect the cardiac function in unknown ways, presumably because age-related changes in the heart may cause iron chelation to affect the cardiac function in different ways. We therefore followed the left ventricular ejection fraction (LVEF) by multigated radionuclide angiography in 16 iron-loaded ANT-patients during iron chelation alone and after increasing the efficacy of chelation by vitamin C supplementation. During 12 months of iron chelation the mean LVEF fell significantly from 63.3% to 58.0% (p = 0.04). Individual changes in LVEF did not correlate significantly with age but with the pretreatment liver iron concentration. After initiation of vitamin C supplementation, the mean LVEF increased from 55.9% to 65.3% (p = 0.01). Our data suggest that in ANT-patients prolonged desferrioxamine treatment without vitamin C supplementation may be associated with reduced LVEF, whereas vitamin C supplementation seems to benefit the cardiac function. Similar findings have not been described in s-thalassaemia and may hence be specific for ANT-patients. However, our findings have to be confirmed by controlled studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text