Reliability range of model parameters and its application to biological models
| Autor: | M. Hájek, J. Potůček, V. Brodan |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Engineering
Mathematical model Basis (linear algebra) business.industry Applied Mathematics Lipoprotein formation Model parameters Range (mathematics) Modelling and Simulation Modeling and Simulation Hybrid computer Sensitivity (control systems) business Biological system Reliability (statistics) Simulation |
| Zdroj: | Applied Mathematical Modelling. 3:199-204 |
| ISSN: | 0307-904X |
| DOI: | 10.1016/0307-904x(79)90051-9 |
| Popis: | This paper deals with the analysis of the determinability of the parameters of mathematical models of biological systems and the estimation of the reliability range of the parameter vectors. The results of the analysis are used to design further experiments for improving the estimation of the parameters. This procedure was illustrated by the investigation of intravenous radiopalmitate kinetics in rats with a special regard to the speed of labelled fatty acid outflow from plasma and lipoprotein formation in the liver. On the basis of the course of parameter sensitivity functions a new theoretical experiment, contributing to a marked improvement of the parameter reliability estimation, was designed. The method was algorithmized in the HYPER and EIGEN programs developed for the EAI690 hybrid computer system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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