Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer
| Autor: | Hyung Ho Kim, Yujun Park, Sang Hoon Ahn, Woo Ho Kim, Jiwon Koh, Hye Seung Lee, Yoonjin Kwak, Do Joong Park |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_treatment Immunology Human leukocyte antigen B7-H1 Antigen Young Adult 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Antigen HLA Antigens Stomach Neoplasms Biomarkers Tumor Tumor Microenvironment medicine Humans Immunology and Allergy Cytotoxic T cell Aged Neoplasm Staging Aged 80 and over business.industry Beta-2 microglobulin Microsatellite instability Immunotherapy Middle Aged medicine.disease HLA-A Oncology Cancer research Female Microsatellite Instability beta 2-Microglobulin business CD8 Follow-Up Studies 030215 immunology |
| Zdroj: | Cancer Immunology, Immunotherapy. 68:1779-1790 |
| ISSN: | 1432-0851 0340-7004 |
| Popis: | Human leukocyte antigen class I (HLA I) molecules composed of alpha (heavy) chain, including HLA-A, -B, or -C encoded by HLA genes, and beta-2-microglobulin (β2M) are membrane proteins on all nucleated cells that display peptide antigens for recognition by CD8-positive cytotoxic T cells. Here, we examined the clinicopathologic signification of HLA I expression in patients with gastric cancer (GC). Immunohistochemistry was performed to detect HLA A/B/C, β2M, CD8, p53, and programmed death-ligand 1 (PD-L1) in the center and invasive margin of the tumor in 395 stage II and III GCs using tissue array method. Additionally, Epstein–Barr virus (EBV) infection and microsatellite instability (MSI) status were investigated. Negative expression of HLA A/B/C and β2M was observed in 258 (65.3%) and 235 (59.5%) of 395 stage II and III GCs, respectively. Negative HLA I expression was significantly associated with aggressive clinicopathologic features. Furthermore, negative expression of HLA A/B/C and β2M was inversely correlated with CD8-positive cytotoxic T cell infiltration, EBV-positivity, and PD-L1 expression (all p |
| Databáze: | OpenAIRE |
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