Human papillomavirus in vulvar squamous-cell carcinoma and in normal vulvar tissues: a search for a possible impact of HPV on vulvar cancer prognosis
| Autor: | Birgitte Kringsholm, Jakob Visfeldt, Ulla Hørding, Søren Daugaard, Benny Andreasson, Johannes E. Bock |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Vulvar Squamous Cell Carcinoma Molecular Sequence Data Biology medicine.disease_cause Herpesviridae Vulva medicine Humans Papillomaviridae Vulvar Diseases Aged Aged 80 and over Intraepithelial neoplasia Base Sequence Vulvar Neoplasms Age Factors virus diseases DNA Neoplasm Vulvar cancer Middle Aged medicine.disease Prognosis female genital diseases and pregnancy complications medicine.anatomical_structure Oncology DNA Viral Cancer research Carcinoma Squamous Cell Female Vulvar Carcinoma Carcinogenesis Precancerous Conditions |
| Zdroj: | International journal of cancer. 55(3) |
| ISSN: | 0020-7136 |
| Popis: | Paraffin-embedded sections of vulvar squamous-cell carcinomas and of normal vulvar tissues were examined for HPV types 6, 11, 16, 18 and 33 by the polymerase chain reaction. Overall, 19 of 62 tumours harboured HPV DNA of types 16, 18 or 33. HPV types 6 and 11 were not detected. HPV DNA was found in 61% of tumours with adjacent intraepithelial neoplasia (VIN III), and in 13% of tumours without associated VIN III. HPV DNA was not detected in any of 101 normal vulvar tissues. HPV DNA was found more often in younger women, in patients with VIN III-associated tumours, and in those with multicentric anogenital neoplasia. This points to the existence of a subset of vulvar carcinomas preceded by intraepithelial neoplasia, with HPV as a major factor in carcinogenesis. HPV also seems to be an important factor in the development of multiprimaries in these patients. The 2 groups of patients with vulvar carcinoma did not differ with regard to prognosis, as estimated by the risk of recurrence after primary surgery. |
| Databáze: | OpenAIRE |
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