Glyceollins, One of the Phytoalexins Derived from Soybeans under Fungal Stress, Enhance Insulin Sensitivity and Exert Insulinotropic Actions
Autor: | Hyo Jung Kim, Jong-Sang Kim, Sunmin Park, Jeong Hwan Kim, Mee Ryung Lee, Il Sung Ahn |
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Rok vydání: | 2010 |
Předmět: |
medicine.medical_specialty
Pterocarpans medicine.medical_treatment Glucose uptake Enteroendocrine cell Biology Carbohydrate metabolism Glucagon Cell Line Mice chemistry.chemical_compound 3T3-L1 Cells Insulin-Secreting Cells Internal medicine Adipocytes medicine Animals Insulin Glucose homeostasis Glyceollin Plant Extracts General Chemistry Glucose Endocrinology chemistry Unfolded protein response Soybeans General Agricultural and Biological Sciences Rhizopus |
Zdroj: | Journal of Agricultural and Food Chemistry. 58:1551-1557 |
ISSN: | 1520-5118 0021-8561 |
Popis: | Glyceollins are a category of phytoalexins that are produced by soybeans under fungal stress, but their effects on glucose homeostasis remain unknown. We hypothesized that glyceollins play an important role in glucose homeostasis by regulating glucose utilization in adipocytes and improving beta-cell function and survival. Glyceollins improved insulin-stimulated glucose uptake in 3T3-L1 adipocytes without activating the peroxisome proliferator-activated receptor-gamma agonist. They decreased triacylglycerol accumulation in adipocytes. In addition, glyceollins slightly improved glucose-stimulated insulin secretion without palmitate treatment in Min6 cells, and they potentiated insulinotropic actions when 500 microM palmitate was used to induce beta-cell dysfunction. This was associated with decreased beta-cell apoptosis because of the attenuation of endoplasmic reticulum stress, as determined by mRNA levels of XBP-1, ATF-4, ATF-6, and CHOP. Glyceollins also potentiated GLP-1 secretion to enhance insulinotropic actions in enteroendocrine cells. In conclusion, glyceollins help normalize glucose homeostasis by potentiating beta-cell function and survival and improving glucose utilization in adipocytes. |
Databáze: | OpenAIRE |
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