Hypersecretion of follicle-stimulating hormone (FSH) on estrous afternoon in rats treated with RU486 in proestrus
| Autor: | José E. Sánchez-Criado, M. Tebar, Antonio Ruiz |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
endocrine system
medicine.medical_specialty Ovariectomy Gonadotropin-releasing hormone Metestrus Gonadotropin-Releasing Hormone Cellular and Molecular Neuroscience Follicle-stimulating hormone chemistry.chemical_compound Hormone Antagonists Estrus Ovarian Follicle Pituitary Gland Anterior Internal medicine medicine Animals Ovarian follicle Progesterone reproductive and urinary physiology Estrous cycle Estradiol urogenital system Ovary Cell Biology General Medicine Luteinizing Hormone Follicular fluid Circadian Rhythm Rats Mifepristone Endocrinology medicine.anatomical_structure chemistry Estradiol benzoate Ovariectomized rat Cattle Female Proestrus Follicle Stimulating Hormone Secretory Rate Luteinizing hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Cellular and Molecular Neurobiology. 16:421-426 |
| ISSN: | 1573-6830 0272-4340 |
| DOI: | 10.1007/bf02088107 |
| Popis: | 1. Intact or ovariectomized (OVX) cyclic rats injected or not with RU486 (4 mg/0.2 ml oil) from proestrus onwards were bled at 0800 and 1800 h on proestrus, estrus and metestrus. Additional RU486-treated rats were injected with: LHRH antagonist (LHRHa), estradiol benzoate (EB) or bovine follicular fluid (bFF) and sacrificed at 1800 h in estrous afternoon. LH and FSH serum levels were determined by RIA. 2. RU486-treated intact or OVX rats had decreased preovulatory surges of LH and FSH, abolished secondary secretion of FSH and hypersecretion of FSH in estrous afternoon. The latter was decreased by LHRHa and abolished by EB or bFF. In contrast, EB induced an hypersecretion of LH in RU486-treated rats at 1800 h in estrus. 3. It can be concluded that in the absence of the proestrous progesterone actions, the absence of the inhibitory effect of the ovary in estrus evoked a LHRH independent secretion of FSH. |
| Databáze: | OpenAIRE |
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