Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy
| Autor: | Ming Cheng Wei, Shiaw-Pyng Wey, Kun-Ju Lin, Chun Min Liu, Hsiang-Wen Tseng, Hao-Li Liu, Chia Chen Lin, Chih Peng Liu, Hsing-Wen Sung, Ko Jie Chen, Felice Cheng, Er Yuan Chaung |
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| Rok vydání: | 2014 |
| Předmět: |
Hyperthermia
Biodistribution Hot Temperature Materials science medicine.medical_treatment Mice Nude General Physics and Astronomy Antineoplastic Agents Pharmacology Mice Cell Line Tumor medicine Animals Humans Tissue Distribution General Materials Science Doxorubicin Whole blood Tomography Emission-Computed Single-Photon Drug Carriers Mice Inbred BALB C Chemotherapy Liposome Antibiotics Antineoplastic General Engineering Technetium Hyperthermia Induced Carbon Dioxide medicine.disease Bicarbonates Liposomes Drug delivery Tomography X-Ray Computed Drug carrier medicine.drug |
| Zdroj: | ACS Nano. 8:5105-5115 |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | As is widely suspected, lysolipid dissociation from liposomes contributes to the intravenous instability of ThermoDox (lysolipid liposomes), thereby impeding its antitumor efficacy. This work evaluates the feasibility of a thermoresponsive bubble-generating liposomal system without lysolipids for tumor-specific chemotherapy. The key component in this liposomal formulation is its encapsulated ammonium bicarbonate (ABC), which is used to actively load doxorubicin (DOX) into liposomes and trigger a drug release when heated locally. Incubating ABC liposomes with whole blood results in a significantly smaller decrease in the retention of encapsulated DOX than that by lysolipid liposomes, indicating superior plasma stability. Biodistribution analysis results indicate that the ABC formulation circulates longer than its lysolipid counterpart. Following the injection of ABC liposome suspension into mice with tumors heated locally, decomposition of the ABC encapsulated in liposomes facilitates the immediate thermal activation of CO2 bubble generation, subsequently increasing the intratumoral DOX accumulation. Consequently, the antitumor efficacy of the ABC liposomes is superior to that of their lysolipid counterparts. Results of this study demonstrate that this thermoresponsive bubble-generating liposomal system is a highly promising carrier for tumor-specific chemotherapy, especially for local drug delivery mediated at hyperthermic temperatures. |
| Databáze: | OpenAIRE |
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