Comorbidity and early death in Danish stage I lung cancer patients – an individualised approach

Autor:	Susanne Oksbjerg Dalton, Karin Holmskov Hansen, Niels Lyhne Christensen, Torben Riis Rasmussen, Jane Christensen
Rok vydání:	2020
Předmět:	Male Oncology medicine.medical_specialty Lung Neoplasms Denmark Early death Comorbidity 030218 nuclear medicine & medical imaging Danish 03 medical and health sciences 0302 clinical medicine Cause of Death health services administration Internal medicine mental disorders Odds Ratio medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Aged Aged 80 and over Stage I Lung Cancer Mortality Premature business.industry Mental Disorders Age Factors Hematology General Medicine Middle Aged Prognosis medicine.disease language.human_language Logistic Models Case-Control Studies 030220 oncology & carcinogenesis language Female business
Zdroj:	Christensen, N L, Rasmussen, T R, Hansen, K H, Christensen, J & Dalton, S O 2020, ' Comorbidity and early death in Danish stage I lung cancer patients–an individualised approach ', Acta Oncologica, vol. 59, no. 8, pp. 994-1001 . https://doi.org/10.1080/0284186X.2020.1764096 Christensen, N L, Rasmussen, T R, Hansen, K H, Christensen, J & Dalton, S O 2020, ' Comorbidity and early death in Danish stage I lung cancer patients-an individualised approach ', Acta Oncologica, vol. 59, no. 8, pp. 994-1001 . https://doi.org/10.1080/0284186X.2020.1764096
ISSN:	1651-226X 0284-186X
Popis:	Background: Comorbidity is an important prognostic marker and a treatment indicator for lung cancer patients. Register-based studies often describe the burden of comorbidity by the Charlson comorbidity index (CCI) based on hospital discharge data. We assessed the association between somatic and psychiatric comorbidity and death within one year in early lung cancer and, furthermore, the burden of comorbidity according to treatment type. Material and methods: We conducted a population-based matched case-control study of stage I lung cancer identifying all treated patients who died (all-cause) within one year after diagnosis (early death group, cases). On the basis of data from the Danish Lung Cancer Registry these patients were then matched with two controls who survived more than one year (survivors). Through a review of the medical records, we validated inclusion criteria and collected data on somatic and psychiatric comorbidity. We assessed the association between comorbidity and early death with multivariate conditional logistic regression. Results: We included 221 cases and 410 controls. The mean CCI score in the early death group was 2.3 vs. 1.3 in the survivor group (p
Databáze:	OpenAIRE
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