Clinical implication of body size phenotype on heart rate variability
| Autor: | Soon Young Hwang, Dong Joo Oh, Kyung Mook Choi, Eung Joo Kim, Chang Gyu Park, Hye Jin Yoo, Sei Hyun Baik, Eun Mi Lee, Seung-Woon Rha, Hong Seog Seo |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Body size Body Mass Index Fasting glucose Correlation 03 medical and health sciences 0302 clinical medicine Endocrinology Asian People Heart Rate Risk Factors Internal medicine Republic of Korea medicine Heart rate variability Body Size Humans Obesity Aged Retrospective Studies Metabolic Syndrome Anthropometry business.industry Body Weight Middle Aged medicine.disease Phenotype Electrocardiography Ambulatory Female Metabolic syndrome Waist Circumference business Body mass index circulatory and respiratory physiology |
| Zdroj: | Metabolism: clinical and experimental. 65(11) |
| ISSN: | 1532-8600 |
| Popis: | We compared heart rate variability (HRV) values according to the following body size phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy but normal weight (MUNW), metabolically healthy but obese (MHO), and metabolically unhealthy obese (MUO). We retrospectively analyzed a dataset from 1200 participants who had visited the Cardiovascular Center at Korea University Guro Hospital between March 2009 and February 2014 and underwent Holter monitoring for 24h. HRV was calculated from standard deviation of normal-to-normal R-R intervals (SDNN), standard deviation of the average normal-to-normal intervals (SDANN), and root mean square of successive differences (rMSSD) measurements, and study subjects were classified according to body mass index (BMI) and presence or absence of metabolic syndrome. Various HRV indices, including SDNN, SDANN, and rMSSD, were significantly lower in MUNW subjects than in MHNW or MHO subjects, while there were no significant differences between MUNW and MUO subjects. Although BMI had no significant correlation with any HRV indices, SDNN, SDANN, and rMSSD values had significant negative correlations with waist circumference and levels of C-reactive proteins, AST, ALT, fasting glucose, and HOMA-IR. A significant positive correlation was observed between HRV index and HDL level. Furthermore, the SDNN value significantly decreased with an increase in the number of metabolic syndrome components after adjusting for other covariates. Compared to MHNW or MHO subjects, Korean men and women with the MUNW phenotype exhibited decreased HRV, suggesting that low HRV is related to adverse cardiovascular outcomes in MUNW individuals. |
| Databáze: | OpenAIRE |
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