Maternal medication use and the risk of brain tumors in the offspring: The SEARCH international case-control study

Autor: Graziella Filippini, A. H. Cardy, Raphael Peris-Bonet, Margaret R. E. McCredie, William Lijinsky, Beth A. Mueller, Julian Little, N. Won Choi, Elizabeth A. Holly, Flora Lubin, Sylvanie Cordier, Susan Preston-Martin, Annie Arslan, Roberta McKean-Cowdin
Přispěvatelé: Epidemiology and Community Medicine, University of Ottawa [Ottawa], Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto Neurologico C. Besta, Chaim Sheba Medical Center, University of Otago [Dunedin, Nouvelle-Zélande], National Childhood Cancer Registry of Spain (RNTI-SEOP), Universitat de València (UV), USC/Norris Comprehensive Cancer Center, University of Southern California (USC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2005
Předmět:
Male
Cancer Research
MESH: Maternal-Fetal Exchange
MESH: Pregnancy
0302 clinical medicine
Pregnancy
Risk Factors
MESH: Risk Factors
MESH: Child
Recall bias
Epidemiology
Medicine
030212 general & internal medicine
Amines
Child
Maternal-Fetal Exchange
education.field_of_study
Brain Neoplasms
N-nitroso compounds
MESH: Amines
MESH: Infant
MESH: Amides
MESH: Case-Control Studies
MESH: Mothers
3. Good health
Oncology
Child
Preschool
030220 oncology & carcinogenesis
MESH: Brain Neoplasms
Female
Disease Susceptibility
Adult
medicine.medical_specialty
Adolescent
Offspring
case-control study
Population
MESH: Disease Susceptibility
Mothers
[SDV.CAN]Life Sciences [q-bio]/Cancer
childhood brain tumors
03 medical and health sciences
Internal medicine
Glioma
maternal medication
Humans
Risk factor
education
MESH: Adolescent
MESH: Humans
business.industry
MESH: Child
Preschool
Case-control study
Infant
MESH: Adult
medicine.disease
Amides
MESH: Male
Case-Control Studies
business
MESH: Female
Zdroj: International Journal of Cancer
International Journal of Cancer, Wiley, 2006, 118 (5), pp.1302-8. ⟨10.1002/ijc.21482⟩
International Journal of Cancer, 2006, 118 (5), pp.1302-8. ⟨10.1002/ijc.21482⟩
ISSN: 0020-7136
1097-0215
DOI: 10.1002/ijc.21482
Popis: International audience; N-nitroso compounds (NOC) have been associated with carcinogenesis in a wide range of species, including humans. There is strong experimental data showing that nitrosamides (R(1)NNO.COR(2)), a type of NOC, are potent neuro-carcinogens when administered transplacentally. Some medications are a concentrated source of amides or amines, which in the presence of nitrites under normal acidic conditions of the stomach can form NOC. Therefore, these compounds, when ingested by women during pregnancy, may be important risk factors for tumors of the central nervous system in the offspring. The aim of the present study was to test the association between maternal use of medications that contain nitrosatable amines or amides and risk of primary childhood brain tumors (CBT). A case-control study was conducted, which included 1,218 cases and 2,223 population controls, recruited from 9 centers across North America, Europe and Australia. Analysis was conducted for all participants combined, by tumor type (astroglial, primitive neuroectodermal tumors and other glioma), and by age at diagnosis (< or =5 years; >5 years). There were no significant associations between maternal intake of medication containing nitrosatable amines or amides and CBT, for all participants combined and after stratification by age at diagnosis and histological subtype. This is the largest case-control study of CBT and maternal medications to date. Our data provide little support for an association between maternal use of medications that may form NOC and subsequent development of CBT in the offspring.
Databáze: OpenAIRE
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