Amygdala and ventral striatum make distinct contributions to reinforcement learning
| Autor: | Elisabeth A. Murray, Vincent D. Costa, Bruno B. Averbeck, Olga Dal Monte, Daniel R. Lucas |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Formative Feedback Decision Making Reversal Learning Striatum Amygdala Choice Behavior Article 03 medical and health sciences 0302 clinical medicine Reward medicine Reaction Time Reinforcement learning Animals Learning Reinforcement General Neuroscience Ventral striatum Dopaminergic Bayes Theorem Macaca mulatta 030104 developmental biology medicine.anatomical_structure Logistic Models Ventral Striatum Psychology Neuroscience Reinforcement Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Popis: | Reinforcement learning (RL) theories posit that dopaminergic signals are integrated within the striatum to associate choices with outcomes. Often overlooked is that the amygdala also receives dopaminergic input and is involved in Pavlovian processes that influence choice behavior. To determine the relative contributions of the ventral striatum (VS) and amygdala to appetitive RL, we tested rhesus macaques with VS or amygdala lesions on deterministic and stochastic versions of a two-arm bandit reversal learning task. When learning was characterized with an RL model relative to controls, amygdala lesions caused general decreases in learning from positive feedback and choice consistency. By comparison, VS lesions only affected learning in the stochastic task. Moreover, the VS lesions hastened the monkeys' choice reaction times, which emphasized a speed-accuracy trade-off that accounted for errors in deterministic learning. These results update standard accounts of RL by emphasizing distinct contributions of the amygdala and VS to RL. |
| Databáze: | OpenAIRE |
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