Nanoparticle-Based Drugs: A Potential Armamentarium of Effective Anti-Cancer Therapies
| Autor: | Inho Choi, Gulam Rabbani, Khurshid Ahmad, Eun Ju Lee, Jeong Ho Lim, Mohammad Hassan Baig, Mohammad Ehtisham Khan, Ghulam Md Ashraf |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_specialty Web of science business.industry Clinical Biochemistry MEDLINE Cancer therapy Cancer Antineoplastic Agents Cancer imaging medicine.disease 03 medical and health sciences Drug Delivery Systems 030104 developmental biology Research strategies Neoplasms medicine Humans Nanoparticles Nanotechnology Nanomedicine Medical physics business Relevant information |
| Zdroj: | Current Drug Metabolism. 19:839-846 |
| ISSN: | 1389-2002 |
| Popis: | BACKGROUND Cancer is a foremost cause of mortality worldwide. Available treatments are non-specific and cannot cross biological barriers, which have restricted their usages. Furthermore, the side effects of existing treatments have promoted the exploration of nanotechnological approaches to achieve site-specific drug delivery. The diminutive sizes of nanoparticles, and hence, their large surface to volume ratios, means they are inherently more efficient at delivering drugs to specific tumor sites. This review highlights different approaches to cancer therapy, and the importance of nanoparticles in cancer therapy. Applications and limitations of different types of nanomedicines used for cancer imaging and treatment are discussed. METHODS We undertook extensive literature search of bibliographic databases (e.g. PubMed, Google Scholar, Medline, Web of Science etc.) using different keywords and combination of keywords to retrieve the relevant information. RESULTS This review provides overview of cancer and need for nanoparticle-based therapies for their treatment, and deliberates the different types of nanomaterials used as nanomedicines for cancer imaging and treatment in addition to their applications and limitations. Furthermore, applications of nanoparticles in modern cancer therapies and research strategies have been explored to overcome cancer. CONCLUSION Nanotechnology has provided a lot of novel therapeutics for the diagnosis and treatment of different cancers over the last 2-3 decades. However, there are few limitations of nanotechnological based anti-cancer therapies. Nanotechnology is enabling novel, specialized treatments for cancer; this will be a high-impact area of nanomedicine yielding more medical advancements with the next 10 years. |
| Databáze: | OpenAIRE |
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