Response to diazepam in children with malaria-induced seizures

Autor:	Simon N. Muchohi, M L Ikumi, Eric O Ohuma, Gilbert Kokwaro, Newton Crjc.
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Male medicine.medical_treatment Neurological disorder Parasitemia Hypnotic Epilepsy 0302 clinical medicine Risk Factors Convulsion 030212 general & internal medicine Malaria Falciparum Child Children 3. Good health Neurology Child Preschool Anesthesia Injections Intravenous Female Anticonvulsants medicine.symptom medicine.drug medicine.medical_specialty medicine.drug_class Paraldehyde Short Communication Malaria Cerebral Clinical Neurology 03 medical and health sciences Seizures Internal medicine parasitic diseases medicine Humans Histidine Retrospective Studies Diazepam business.industry Infant Benzodiazepine receptor Receptors GABA-A medicine.disease Malaria Anticonvulsant Neurology (clinical) business 030217 neurology & neurosurgery
Zdroj:	Epilepsy Research
DOI:	10.1016/j.eplepsyres.2008.08.002
Popis:	Summary Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (χ2 = 3.93, P = 0.047) and those with clinical diagnosis of malaria (χ2 = 9.84, P = 0.002) compared to those without. However malaria was not identified as an independent risk factor for diazepam's failure to stop seizures in children.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67bca547b4e055b147a2bf34b37a3a https://doi.org/10.1016/j.eplepsyres.2008.08.002 Zobrazit plný text záznamu