Properties of the transient outward, ultra-rapid delayed rectifier and acetylcholine-sensitive potassium currents in isolated atrial myocytes from dogs: sinus rhythm and tachypaced model of permanent atrial fibrillation
| Autor: | István Baczkó, Peter Kovacs, Viktor Juhász, Zoltán Husti, László Virág, Attila Kristóf, András Varró, Claudia Corici, Zsófia Kohajda, Norbert Jost |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Potassium Pharmacology toxicology chemistry.chemical_element Atrial fibrillation medicine.disease Delayed rectifier chemistry Internal medicine Meeting Abstract medicine Cardiology Pharmacology (medical) Sinus rhythm cardiovascular diseases Atrial myocytes Patch clamp business Acetylcholine medicine.drug |
| Zdroj: | BMC Pharmacology |
| ISSN: | 1471-2210 |
| Popis: | Background Atrial fibrillation (AF) is a common and severe arrhythmia, which largely affects quality of life. State-of-the-art treatment of AF still relies heavily on pharmacological modalities. Therefore, the aim of the present study was to investigate and compare the properties of three repolarizing currents which contribute to AF-induced remodeling, i.e. the transient outward (Ito), ultra-rapid delayed rectifier (IKur) and acetylcholine-sensitive potassium currents (IK, ACh ) in isolated atrial myocytes obtained from normal (SR) and tachypaced model of permanent atrial fibrillation (ATR) dogs. Methods The tachypaced atrial fibrillation model was performed in dogs. Transmembrane ionic currents were investigated by applying the whole-cell patch clamp technique at 37°C, and ECG was recorded in conscious dogs. |
| Databáze: | OpenAIRE |
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