A study on small-world brain functional networks altered by postherpetic neuralgia
| Autor: | Jue Zhang, Wenxue Fang, Yue Zhang, Minyi Du, Dongxin Wang, Longchuan Li, Xiaoying Wang, Jing Fang, Xiaoping Hu, Xuexiang Jiang, Jing Liu |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Brain activity and meditation Biomedical Engineering Biophysics Neuralgia Postherpetic Audiology urologic and male genital diseases Sensitivity and Specificity medicine Humans Radiology Nuclear Medicine and imaging Aged Pain Measurement Aged 80 and over Brain Mapping Resting state fMRI medicine.diagnostic_test business.industry Postherpetic neuralgia Postcentral gyrus Putamen Chronic pain Brain Reproducibility of Results Pain Perception Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Anesthesia Female Nerve Net business Functional magnetic resonance imaging Parahippocampal gyrus |
| Zdroj: | Magnetic resonance imaging. 32(4) |
| ISSN: | 1873-5894 |
| Popis: | Understanding the effect of postherpetic neuralgia (PHN) pain on brain activity is important for clinical strategies. This is the first study, to our knowledge, to relate PHN pain to small-world properties of brain functional networks. Functional magnetic resonance imaging (fMRI) was used to construct functional brain networks of the subjects during the resting state. Sixteen patients with PHN pain and 16 (8 males, 8 females for both groups) age-matched controls were studied. The PHN patients exhibited decreased local efficiency along with non-significant changes of global efficiency in comparison with the healthy controls. Moreover, regional nodal efficiency was found to be significantly affected by PHN pain in the areas related to sense (postcentral gyrus, inferior parietal gyrus and thalamus), memory/affective processes (parahippocampal gyrus) and emotional activities (putamen). Significant correlation (p |
| Databáze: | OpenAIRE |
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