The problem of accelerated atherosclerosis in systemic lupus erythematosus: Insights into a complex co-morbidity
| Autor: | Nekeithia S. Wade, Amy S. Major |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Time Factors
Autoimmunity Inflammation Comorbidity Disease 030204 cardiovascular system & hematology medicine.disease_cause Risk Assessment Article Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Risk Factors immune system diseases Immunity Animals Humans Lupus Erythematosus Systemic Medicine skin and connective tissue diseases 030203 arthritis & rheumatology Lupus erythematosus business.industry Arteries Hematology Atherosclerosis medicine.disease Disease Models Animal Rheumatoid arthritis Immunology Disease Progression medicine.symptom business |
| Zdroj: | Thrombosis and Haemostasis. 106:849-857 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th11-05-0330 |
| Popis: | SummaryRheumatic autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE), are associated with antibodies to “self” antigens. Persons with autoimmune diseases, most notably SLE, are at increased risk for developing accelerated cardiovascular disease. The link between immune and inflammatory responses in the pathogenesis of cardiovascular disease has been firmly established; yet, despite our increasing knowledge, accelerated atherosclerosis continues to be a significant co-morbidity and cause of mortality in SLE. Recent animal models have been generated in order to identify mechanism(s) behind SLE-accelerated atherosclerosis. In addition, clinical studies have been designed to examine potential treatments options. This review will highlight data from recent studies of immunity in SLE and atherosclerosis and discuss the potential implications of these investigations. |
| Databáze: | OpenAIRE |
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