Evidence of a thyrotropin-releasing activity of ovine corticotropin-releasing factor in the domestic fowl (Gallus domesticus)
| Autor: | Eduard Kühn, Luc Berghman, Stephen Kotanen, Kris Geris, Veerle Darras |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Thyroid Hormones Time Factors Corticotropin-Releasing Hormone Thyrotropin Chick Embryo Biology Iodide Peroxidase chemistry.chemical_compound Follicle-stimulating hormone Endocrinology Adrenocorticotropic Hormone Corticosterone Pituitary Hormones Anterior Internal medicine medicine Animals Tissue Distribution Triiodothyronine Sheep Luteinizing Hormone Prolactin Thyroxine Somatostatin chemistry Glycoprotein Hormones alpha Subunit Injections Intravenous Animal Science and Zoology Cattle Thyroid function Luteinizing hormone Chickens hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | General and comparative endocrinology. 104(2) |
| ISSN: | 0016-6480 |
| Popis: | Ovine corticotropin-releasing factor (oCRF) administered to 19-day-old chicken embryos (E19) increased plasma concentration of pituitary glycoprotein alpha-subunit concentrations within 15 min for at least 4 hr. Follicle stimulating hormone levels were unchanged, while plasma luteinizing hormone concentrations only began to increase 1 hr after the oCRF treatment. Calculation of circulating thyrotropin (TSH) indicator values revealed a rapid elevation in TSH plasma levels following oCRF. Concentrations of thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), and corticosterone increased from 1 hr postinjection. Hypothalamic outer ring deiodinating type II increased and hepatic inner ring deiodinating type III fell after 2 and 4 hr, explaining at least in part the plasma T3 increase at the end of the experiment. In a second experiment, using E18 chicks, a comparison was made between the effects of a single injection of 2 micrograms oCRF and 20 mlU bovine TSH. Both hormones increased T4, T3, and rT3 plasma concentrations, supporting the hypothesis of a TSH-releasing activity for oCRF in the embryonic chicken. The proposed TSH-mediated effect of CRF on thyroid function was further confirmed in two in vitro experiments in which oCRF did not directly influence the thyroidal T4 secretion but, when applied to pituitaries, clearly increased the alpha-subunit release. In chickens CRF is concluded to not only control the adrenal axis, but also to participate in the coordination of avian TSH release. |
| Databáze: | OpenAIRE |
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