Long-term stable efficacy of botulinum toxin A in facial movement disorders with no need for increasing dose
| Autor: | Zvi Susel, Yazid Badarny, Rema Nasar, Raphiq Ibrahim, Samih Badarny, Adnan Zaina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
botox
Adult Male long term efficacy Adolescent Synkinesis Blepharospasm Observational Study Facial Muscles Botulinum toxin a Injections 03 medical and health sciences Young Adult 0302 clinical medicine dysport Effective treatment Medicine hemifacial spasm Humans In patient 030212 general & internal medicine Facial movement Botulinum Toxins Type A Adverse effect Aged Retrospective Studies Aged 80 and over Dose-Response Relationship Drug business.industry Drug Substitution General Medicine Middle Aged medicine.disease Long-Term Care Treatment efficacy Treatment Outcome Neuromuscular Agents 030220 oncology & carcinogenesis Anesthesia Female business stable dose Hemifacial spasm Research Article Follow-Up Studies Muscle Contraction |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Botulinum toxin A is considered an effective treatment for involuntary facial movements. We examined whether treatment efficacy maintained or changed over time with two products, Botox and Dysport, in patients with hemifacial spasm, facial synkinesis and benign essential blepharospasm. We retrospectively investigated 87 consecutive patients (51 women, 36 men) who had undergone treatment for ≥6 years. Long-term effects, as well as side effects of Botox or Dysport local injections were evaluated. The first three treatments were considered the titration period and not taken into account when testing for dose changes. Mean treatment duration was 10 years (range 6–11, SD 1.0), 2441 treatments were administered, 1162 with Botox and 1279 with Dysport, the two brands were interchanged as needed. Good to full improvement was seen in 90% of patients both with both brands. Injection doses and treatment responses were consistent during the study with both drugs. No major side effects were reported, and relatively few minor adverse events were reported, with clear reduction from the titration period (6.1%), to the remainder of the study (3.9%). Botulinum toxin (BTX-A) is a satisfactory long-term treatment without need for dose increase over. Both Botox and Dysport were effective when used interchangeably. |
| Databáze: | OpenAIRE |
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