15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice
| Autor: | R. R. Bartlett, F. R. Seiler, H. U. Schorlemmer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Immunology Renal function Mice Inbred Strains Toxicology Guanidines Autoimmune Diseases Arthritis Rheumatoid Mice Glomerulonephritis Rheumatoid Factor Internal medicine medicine Animals Lupus Erythematosus Systemic Rheumatoid factor Pharmacology (medical) skin and connective tissue diseases Autoantibodies Pharmacology Autoimmune disease business.industry Autoantibody Swollen lymph nodes medicine.disease Rheumatology Endocrinology Rheumatoid arthritis Female Polyarthritis medicine.symptom business Immunosuppressive Agents Injections Intraperitoneal |
| Zdroj: | Agents and Actions. 34:151-155 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01993264 |
| Popis: | Treating MRL/1pr mice, which spontaneously develop systemic lupus erythematosus and rheumatoid arthritis, with 15-DOS resulted in a decrease in the amount of autoantibodies and inhibited proteinuria of the developing glomerulonephritis with an improved survival rate of these autoimmune mice. 15-DOS treatment also lowered the percentage of animals with swollen lymph nodes and inhibited the development of splenomegaly. In the established disease 15-DOS returned urine-protein values and renal function (serum urea and creatinine) to normal levels. Circulating rheumatoid factor and autoantibodies to double-stranded DNA were reduced and the increase in paw volume (signs of a polyarthritis) was inhibited. |
| Databáze: | OpenAIRE |
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