Immunohistochemical signaling pathways of triple negative and triple positive breast cancers: What is new?
| Autor: | Nermeen Abdel-Moneim H. Kamel, Asmaa M. Ahmed, Dalia A. Elsers, Eman Mostafa Masoud |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Perineural invasion Breast Neoplasms Triple Negative Breast Neoplasms Pathology and Forensic Medicine Pathogenesis Breast cancer Humans Medicine Stage (cooking) business.industry General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Phenotype DNA-Binding Proteins Androgen receptor Treatment Outcome Receptors Androgen Cancer research Female Signal transduction business Signal Transduction Transcription Factors |
| Zdroj: | Annals of Diagnostic Pathology. 55:151831 |
| ISSN: | 1092-9134 |
| DOI: | 10.1016/j.anndiagpath.2021.151831 |
| Popis: | Background Breast cancer (BC) is a heterogeneous disease with different clinically heterogeneous phenotypes. Triple negative BC (TNBC) (ER-/PR-/HER2-) and triple positive BC (TPBC) (ER+/PR+/HER2+) are characterized by unique clinical behavior and therapeutic challenges. However, their exact molecular pathogenesis is not well studied. This study aims to evaluate the immunohistochemical expression of androgen receptor (AR) and c-Myc in TPBCs and TNBCs, correlate their expression with the clinicopathologic features, and assess the correlation between AR and c-Myc expression in TPBCs and TNBCs. Material and methods AR and c-Myc were immunohistochemically assessed in 45 TNBC and 15 TPBC specimens. Results AR expression was detected in 17.7% of TNBC and in all TPBC specimens. c-Myc was expressed in 46.7% of TNBC and in all TPBC specimens. AR and c-Myc expression in TNBC was not associated with any of the clinicopathological features. In TPBC, AR expression was higher in older age, larger size, higher stage, and lymph node metastasis while c-Myc expression was higher in tumors with perineural invasion. This is the first study that reported a significant positive correlation between AR and c-Myc expression in TNBC and TPBC. Conclusion The current results suggested that AR and c-Myc proteins may contribute to the pathogenesis of TNBC and TPBC. The positive correlation between the two proteins in these subtypes sheds new light on a distinct pathway by which BC cells can modulate their proliferation. Targeting both molecules may provide new therapeutic approaches to improve therapeutic sensitivity and patients' outcomes of these subtypes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect