Factors predicting non-ventilated hospital-acquired pneumonia: systematic review and meta-analysis

Autor: Franciele Anziliero, Stephani Amanda Lukasewicz Ferreira, Patricia Klarmann Ziegelmann, Ricardo de Souza Kuchenbecker, Camila Hubner Dalmora
Rok vydání: 2022
Předmět:
Zdroj: Journal of Hospital Infection. 119:64-76
ISSN: 0195-6701
Popis: Summary Background Hospital acquired pneumonia (HAP) results in approximately 15 to 20% of all infections in hospitals, with more than two thirds being in patients not using mechanical ventilation. The incidence of non-ventilated hospital-acquired pneumonia (NVHAP) is increasing, and it is associated with a longer length of stay, the need for intensive care unit (ICU) hospitalization and mechanical ventilation use, and higher mortality. Objective To identify, quantify, and summarize predictor factors for NVHAP in adult patients admitted to non-intensive care units as determined by previous observational studies. Methods We systematically searched PubMed, EMBASE, Scopus, and LILACS. Case-control and cohort studies were included, and a meta-analysis was performed for all factors studied more than once. National Institute of Health assessment tools were applied to assess the quality of the studies. Results Thirty-eight articles showing 204 predictor factors were included. A meta-analysis was performed for 58 factors, 32 of which were significantly associated with NVHAP. When the sensitivity analysis was performed without poor quality studies, 24 factors remained associated with NVHAP. Conclusion Although there is a lack of good quality studies to establish predictor factors for NVHAP, the results of this study showed 24 factors associated with the development of this infectious complication. The knowledge of the significant predictor factors for NVHAP will enable the identification of patients most likely to develop it. Key words: hospital acquired pneumonia; predictor factor; prevention.
Databáze: OpenAIRE
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