R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. A GEL/TAMO study

Autor:	Angel Leon, Concepción Ruiz, Eva González-Barca, Juan M. Sancho, Alejandro Martín, Eulogio Conde, Antonio Salar, Guillermo Deben, María-José Requena, Miguel Canales, M. D. Caballero, Lourdes Vázquez, Sara Nistal, Jose J. Gonzalez, Montserrat Arnan, Pedro Garcia-Sanchez, Eva M. Donato, Carlos Grande, Rafael Andreu
Přispěvatelé:	Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea (GEL/TAMO cooperative group), [Martín,A] Complejo Hospitalario de Zamora. [Conde,E] Hospital Marqués de Valdecilla, Santander. [Arnan,M, González-Barca,E] Hospital Duran i Reynals, L’Hospitalet de Llobregat. [Canales,MA] Hospital La Paz, Madrid, [Deben,G] Hospital Juan Canalejo, La Coruña. [Sancho,JM] Hospital Germans Trias i Pujol, Badalona. [Andreu,R] Hospital Dr. Peset, Valencia. [Salar,A] Hospital del Mar, Barcelona. [García-Sanchez,P] Hospital Clínico de Madrid. [Vázquez,L, Caballero,MD] Hospital Universitario de Salamanca. [Nistal,S] Hospital Universitario de Getafe. [Requena,MJ] Hospital Severo Ochoa, Leganés. [Donato,EM] Hospital General de Castellón. [González, JA] Hospital Virgen del Puerto, Plasencia. [León,A] Hospital General de Jerez, Jerez de la Frontera. [Ruiz,C] Hospital Carlos Haya, Málaga. [Grande,C] Hospital Doce de Octubre, Madrid, Spain.
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Linfoma de células B grandes difuso Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy::Salvage Therapy [Medical Subject Headings] medicine.medical_specialty Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings] Chemicals and Drugs::Inorganic Chemicals::Chlorine Compounds::Cisplatin [Medical Subject Headings] Salvage therapy Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Pyrimidines::Pyrimidine Nucleosides::Cytidine::Cytarabine [Medical Subject Headings] Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] Diseases::Immune System Diseases::Immunoproliferative Disorders::Lymphoproliferative Disorders::Lymphoma::Lymphoma Non-Hodgkin::Lymphoma B-Cell::Lymphoma Large B-Cell Diffuse [Medical Subject Headings] Gastroenterology Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings] hemic and lymphatic diseases Internal medicine medicine Named Groups::Persons::Age Groups::Adult [Medical Subject Headings] Refractory Diffuse Large B-Cell Lymphoma Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies Monoclonal [Medical Subject Headings] Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings] Etoposide Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols::Antineoplastic Protocols::Antineoplastic Combined Chemotherapy Protocols [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings] business.industry Diffuse large B-Cell lymphoma Hematology R-ESHAP medicine.disease Surgery Lymphoma Tratamiento de última línea Chemicals and Drugs::Polycyclic Compounds::Steroids::Steroids Fluorinated::Dexamethasone [Medical Subject Headings] Protocolos de quimioterapia antineoplásica combinada Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings] Cytarabine Rituximab Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies Monoclonal::Antibodies Monoclonal Murine-Derived [Medical Subject Headings] Chemicals and Drugs::Carbohydrates::Glycosides::Glucosides::Etoposide [Medical Subject Headings] business ESHAP Diffuse large B-cell lymphoma medicine.drug
Popis:	Journal Article; Multicenter Study; "Comment in Salvage therapy for relapsed or refractory diffuse large B-cell lymphoma: impact of prior rituximab. [Haematologica. 2008]" (Nota tomada de PubMed) BACKGROUND The role of re-treatment with rituximab in aggressive B-cell lymphomas still needs to be defined. This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP). DESIGN AND METHODS We retrospectively analyzed 163 patients with relapsed or refractory diffuse large B-cell lymphoma who received R-ESHAP as salvage therapy with a curative purpose. Patients were divided into two groups according to whether rituximab had been administered (n=94, "R+" group) or not (n=69, "R-" group) prior to R-ESHAP. RESULTS Response rates were significantly higher in the R- group in the univariate but not in the multivariate analysis. In the analysis restricted to the R+ group, we observed very low complete remission and overall response rates in patients with primary refractory disease (8% and 33%, respectively), as compared to those in patients who were in first partial remission (41% and 86%) or who had relapsed disease (50% and 75%) (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d58158cb300991384e053f3602edd35 https://hdl.handle.net/10668/1286 Zobrazit plný text záznamu