Trigeminal Nitric Oxide Synthase Expression Correlates with New Bone Formation During Distraction Osteogenesis
| Autor: | Rubens Ferreira de Albuquerque, Luiz Guilherme Brentegani, Maria Tereza Moura de Oliveira, João Paulo Mardegan Issa, Elaine Aparecida Del Bel |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment education Cell Osteogenesis Distraction Bone healing Nitric Oxide Bone tissue Models Biological Bone and Bones Nitric oxide Bone remodeling chemistry.chemical_compound Trigeminal ganglion Endocrinology Internal medicine medicine Animals Orthopedics and Sports Medicine Rats Wistar Fracture Healing biology business.industry Anatomy Biomechanical Phenomena Osteotomy Rats Nitric oxide synthase medicine.anatomical_structure Gene Expression Regulation Trigeminal Ganglion chemistry biology.protein Distraction osteogenesis Nitric Oxide Synthase business |
| Zdroj: | Calcified Tissue International. 82:309-315 |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/s00223-008-9107-8 |
| Popis: | Nitric oxide synthase (NOS) has been reported to be involved with both bone healing and bone metabolism. The aim of this study was to test the null hypothesis that there is no correlation between new bone formation during mandibular distraction osteogenesis and NOS expression in the trigeminal ganglion of rats. Newly formed tissue during distraction osteogenesis and trigeminal NOS expression measured by the NADPH-diaphorase (NADPH-d) reaction were evaluated in 72 male Wistar rats by histomorphometric and histochemical methods. In animals submitted to 0.5 mm/day distraction osteogenesis, the percentage of bone tissue was higher in the basal area of the mandibles compared with the center and significantly increased through the experimental periods (P |
| Databáze: | OpenAIRE |
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