MAGE-A family expression is correlated with poor survival of patients with lung adenocarcinoma: a retrospective clinical study based on tissue microarray

Autor: Fei Liu, Shina Liu, Baoen Shan, Danjing Yin, Xiaochong Zhang, Lina Gu, Yunyan Wu, Weina Huang, Yishui Lian, Meixiang Sang
Rok vydání: 2016
Předmět:
Adult
Male
0301 basic medicine
endocrine system
Pathology
medicine.medical_specialty
Lung Neoplasms
Adenocarcinoma of Lung
Cell Cycle Proteins
Kaplan-Meier Estimate
Adenocarcinoma
Biology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Antigen
Biomarkers
Tumor
medicine
Humans
Anaplastic lymphoma kinase
Anaplastic Lymphoma Kinase
Lung cancer
neoplasms
Aged
Retrospective Studies
Gene Rearrangement
Tissue microarray
Serine Endopeptidases
Receptor Protein-Tyrosine Kinases
Cancer
General Medicine
Gene rearrangement
Middle Aged
Prognosis
medicine.disease
Neoplasm Proteins
ErbB Receptors
030104 developmental biology
Tissue Array Analysis
Lymphatic Metastasis
030220 oncology & carcinogenesis
Cancer research
Immunohistochemistry
Female
Melanoma-Specific Antigens
Microtubule-Associated Proteins
Zdroj: Journal of Clinical Pathology. 70:533-540
ISSN: 1472-4146
0021-9746
DOI: 10.1136/jclinpath-2016-203718
Popis: Objectives As the best characterised cancer/testis antigen family members, melanoma-associated antigens (MAGE) have been reported to be expressed in various malignant tumours. However, the expression pattern of MAGE-A family in lung adenocarcinoma (LAC) specimens and their prognostic and therapeutic significance for patients with LAC is still unclear. Materials and methods Tissue microarray-based immunohistochemistry analysis was used to examine the expression of MAGE-A family members (including MAGE-A1, A2, A3, A4, A6, A10, A11 and A12) in 105 paired LAC specimens and the corresponding pericarcinoma specimens. The association between MAGE-A expression and the clinicopathological parameters, and the 10-year overall survival of patients with LAC were analysed. In addition, the association between MAGE-A expression and the epithelial growth factor receptor (EGFR) amplification and ALK-EML4 rearrangements of patients with LAC were also analysed. Results The immunohistochemical evaluation revealed that MAGE-A family was expressed in 46.66% of LAC specimens, but not in the corresponding pericarcinoma specimens. MAGE-A expression was not associated with the clinicopathological factors but with worse 10-year survival, and was a poor prognostic marker for patients with LAC. MAGE-A expression was not correlated with EGFR amplification and ALK rearrangements. Interestingly, MAGE-A expression can affect the overall survival of patients with LAC without EGFR amplification or ALK rearrangements, but not affect the overall survival of patients with LAC and EGFR amplification or ALK rearrangements. Conclusions Molecular assessment of MAGE-A family members could be considered to improve the prognostic evaluation and to provide a new potential therapeutic strategy for patients with LAC.
Databáze: OpenAIRE
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