Iron deficiency during pregnancy and lactation modifies the fatty acid composition of the brain of neonatal rats
Autor: | Harry J McArdle, Lorraine Gambling, Helen E. Hayes, Valerie Joan Stevens, Susan M. Hay, William D. Rees |
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Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Offspring Iron Medicine (miscellaneous) Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Fatty Acids Omega-6 Lactation Internal medicine Fatty Acids Omega-3 medicine Animals Humans Brain Chemistry chemistry.chemical_classification Anemia Iron-Deficiency Pregnancy Complications Hematologic Brain Fatty acid Iron Deficiencies Iron deficiency Lipid Metabolism medicine.disease Animals Suckling Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology Animals Newborn chemistry Docosahexaenoic acid Prenatal Exposure Delayed Effects Saturated fatty acid Female Arachidonic acid 030217 neurology & neurosurgery Polyunsaturated fatty acid |
Zdroj: | Journal of Developmental Origins of Health and Disease. 11:264-272 |
ISSN: | 2040-1752 2040-1744 |
Popis: | Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of female rats fed iron-deficient diets during gestation and lactation. Subsequent to the dams giving birth, one group of iron-deficient dams was recuperated by feeding an iron-replete diet. Dams and neonates were killed on postnatal days 1, 3 and 10, and the fatty acid composition of brain and stomach contents was assessed by gas chromatography. Changes in the fatty acid profile on day 3 became more pronounced on day 10 with a decrease in the proportion of saturated fatty acids and a compensatory increase in monounsaturated fatty acids. Long-chain polyunsaturated fatty acids in the n-6 family were reduced, but there was no change in the n-3 family. The fatty acid profiles of neonatal brain and stomach contents were similar, suggesting that the change in milk composition may be related to the changes in the neonatal brain. When the dams were fed an iron-sufficient diet at birth, the effects of iron deficiency on the fatty acid composition of lipids in both dam’s milk and neonates’ brains were reduced. This study showed an interaction between maternal iron status and fatty acid composition of the offspring’s brain and suggests that these effects can be reduced by iron repletion of the dam’s diet at birth. |
Databáze: | OpenAIRE |
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