Cytomegalovirus seroepidemiology in an urban community of São Paulo, Brazil

Autor: Raymundo Soares Azevedo, L. M Almeida, Marcos Amaku, Eduardo Massad
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Pediatrics
Cytomegalovirus
Force of infection
Antibodies
Viral
Serology
Rubella vaccine
Citomegalovirose
Disease transmission horizontal
Medicine
Child
Mathematical models
education.field_of_study
Transmission (medicine)
lcsh:Public aspects of medicine
Transmissão vertical de doença
Disease transmission vertical
Child
Preschool
Cytomegalovirus Infections
Female
ELISA
Brazil
Age factors
medicine.drug
Adult
medicine.medical_specialty
Adolescent
Infecções por cytomegalovirus
Population
Congenital cytomegalovirus infection
Enzyme-linked immunosorbent assay/utilization
Estudos soroepidemilógicos
Transmissão horizontal de doença
Humans
Seroprevalence
Cytomegalovirus infections/congenital
education
Fatores etários
Retrospective Studies
Cytomegalovirus infections/transmission
business.industry
Cytomegalovirus infections/epidemiology
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
lcsh:RA1-1270
Seroepidemiologic Studies
medicine.disease
Seroepidemiologic studies
Modelos matemáticos
Immunoglobulin G
Immunology
business
Zdroj: Revista de Saúde Pública, Vol 35, Iss 2, Pp 124-129 (2001)
ISSN: 1518-8787
Popis: INTRODUCTION: After the era of rubella vaccine, cytomegalovirus (CMV) infection is one of the most frequently causes of mental retardation and congenital deafness. Seroepidemiological studies are necessary to understand the transmission dynamics of the disease. The purpose of the study was to quantify the transmission rate of CMV disease in a community in the state of São Paulo, Brazil. METHODS: Using ELISA test (IgG), a retrospective serological survey looking for CMV antibodies was performed in an non-immunized community. Frozen sera from 443 individuals, randomly selected by cluster sampling technique in the town of Caieiras, São Paulo, were collected from November 1990 to January 1991. Seroprevalence was stratified by age (0-40 years). Mathematical techniques were applied to determine the age-dependent decay function of maternal antibodies during the first year of life, the age-dependent seroprevalence function and the force of infection for CMV in this community. RESULTS: It was observed a descending phase of seropositivity in the first 9 months, but changes in antibody titration were observed between 8 months old and one year of age. The average age of the first infection was 5.02 months of age and 19.84 years, when the age-dependent seroprevalence and the force of infection were analyzed between 10 months of age and 10 years of age and from 10 to 40 years old, respectively. CONCLUSION: CMV infection is highly prevalent among the population studied and infection occurs in the first year of life. This study shows that most women at reproductive age are vulnerable to the first infection, increasing the risk for congenital infection.
Databáze: OpenAIRE
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