Usefulness of Alanine and Aspartate Aminotransferases in the Diagnosis of Microlithiasis in Idiopathic Acute Pancreatitis
| Autor: | Pedro Almela, José M. Rodrigo, Daniel Bautista, A Peña, Isabel Pascual, Francisco Grau, L. Aparisi |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Abdominal pain Pancreatic disease Aspartate transaminase digestive system Gastroenterology Endocrinology Cholelithiasis Internal medicine medicine Humans Aspartate Aminotransferases Biliary microlithiasis Aged Retrospective Studies Aged 80 and over Univariate analysis biology business.industry Alanine Transaminase Middle Aged medicine.disease digestive system diseases Pancreatitis Oncology Alanine transaminase Acute Disease biology.protein Acute pancreatitis Female medicine.symptom business Biomarkers |
| Zdroj: | International Journal of Gastrointestinal Cancer. 25:107-112 |
| ISSN: | 1537-3649 |
| DOI: | 10.1385/ijgc:25:2:107 |
| Popis: | Background. It has been shown that biochemical laboratory values only are useful parameters in distinguishing gallstone from nongallstone acute pancreatitis. We assessed the diagnostic usefulness of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) for identification of occult microlithiasis in idiopathic acute pancreatitis. Methods. Ninety-one patients with idiopathic acute pancreatitis who underwent microscopic examination of stimulated duodenal bile sediments were retrospectively studied. According to earliness of ALT and AST assay after the onset of abdominal pain, patients were divided into two groups: group A, within the first 24 h (n=56) and group B, between 24 and 72 h (n=35). Results: ALT and AST values expressed as number of elevations of the upper limits of normal were higher in group A patients with positive biliary drainage than in group B. Median (range) ALT and AST values were 2.5 (0.1–18.1) vs 0.4 (0.1–8.6) and 3 (0.3–17.4) vs 0.5 (0.3—11.9), respectively. In the univariate analysis and receiver operating characteristic (ROC) curves, ALT within the first 24 h showed a sensitivity of 73%, specificity of 86%, and positive predictive value of 92% for a cutoff of 1.2 elevations of the upper limit of normal. These values were slightly higher, although without statistically significant differences, than those of AST (73, 80, and 89%, respectively). Conclusion. Serum increases of aminotransferases, especially alanine aminotransferase (ALT), were suggestive of microlithiasis in idiopathic acute pancreatitis, particularly when assessed early after the onset of abdominal pain. |
| Databáze: | OpenAIRE |
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